2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N1798
    Quercetin 3,7-dimethyl ether 2068-02-2 98%
    Quercetin 3,7-dimethyl ether, isolated from Croton schiedeanus Schlecht, has a NO/cGMP pathway-related profile, with increased vasorelaxant activity.
    Quercetin 3,7-dimethyl ether
  • HY-N1861
    3-O-Methylquercetin tetraacetate 1486-69-7 98%
    3-O-Methylquercetin tetraacetate is an antiplatelet agent. 3-O-Methylquercetin tetraacetate has potent antiplatelet effect on arachidonic acid, collagen-induced and PAF-induced platelet aggregation.
    3-O-Methylquercetin tetraacetate
  • HY-N1904
    4′-Hydroxywogonin 57096-02-3 98%
    4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis.
    4′-Hydroxywogonin
  • HY-N1982
    Denudatine 26166-37-0 98%
    Denudatine, is primarily isolated from plants of the genera Aconitum and Delphinium. Denudatine has effects on action potential of ventricular fibers and inhibits arrhythmogenic action of aconitine.
    Denudatine
  • HY-N2190
    Hederagenin 28-O-beta-D-glucopyranosyl ester 53931-25-2 99.04%
    Hederagenin 28-O-beta-D-glucopyranosyl ester, a triterpenoid saponin isolated from Ilex cornuta, exhibits protective effects against H2O2-induced myocardial cell injury.
    Hederagenin 28-O-beta-D-glucopyranosyl ester
  • HY-N2892
    Aristolactam A IIIa 97399-91-2 98%
    Aristolactam A IIIa (Sch 546909) is an aristolactam-type alkaloid that can be isolated from Glycosmis chlorosperma. Aristolactam A IIIa is a DYRK1A Inhibitor. Aristolactam A IIIa inhibits platelet aggregation induced by arachidonic acid (AA), collagen and platelet-activating factor (PAF). Aristolactam A IIIa has strong cytotoxic effect on HeLa cells.
    Aristolactam A IIIa
  • HY-N2924
    β-Amyrin palmitate 5973-06-8 98%
    β-Amyrin palmitate shows HMG-CoA reductase inhibition. And β-Amyrin palmitate has anti-diabetes mellitus activity.
    β-Amyrin palmitate
  • HY-N2960
    Broussonin A 73731-87-0 98%
    Broussonin A is a potent BChE inhibitor, with an IC50 of 4.16 µM. Broussonin A is a diarylpropane natural product that can be isolated from the bark of Broussonetia papyrifera after solid fermentation.
    Broussonin A
  • HY-N3048
    Piperlotine D 958296-13-4 98%
    Piperlotine D is an antiplatelet aggregation agent. Piperlotine D can be extracted from Piper lolot with antiplatelet aggregation activity. Piperlotine D inhibits arachidonic acid-induced platelet aggregation with an IC50 of 43.4 μg/mL.
    Piperlotine D
  • HY-N3049
    Piperlotine C 886989-88-4 98%
    Piperlotine C is an alkaloid isolated from Piper lolot, with anti-platelet aggregation induced by arachidonic acid, and the IC50 is 26.6 µg/mL.
    Piperlotine C
  • HY-N3051
    Piperlotine A 389572-70-7 98%
    Piperlotine A is an alkaloid isolated from Piper lolot, with potent antiplatelet aggregation activity.
    Piperlotine A
  • HY-N3164
    Oblongine 60008-01-7 98%
    Oblongine is isolated from the tuber of Stephania cambodica.
    Oblongine
  • HY-N3167
    Nyasicoside 111518-94-6 98%
    Nyasicoside is a norlignan glucosides that can be isolated from Curculigo capitulate. Nyasicoside has potent activity against ouabain-induced arrhythmia in the heart preparations of guinea pig.
    Nyasicoside
  • HY-N3202
    Neolitsine 2466-42-4 98%
    Neolitsine ((+)-Neolitsine) is a vasodilator. Neolitsine can be isolated from the herb Cassytha filiformis. Neolitsine exhibits significant vasodilatory effects on precontracted rat aortic preparations with an IC50 of 0.29 μM.
    Neolitsine
  • HY-N3436
    Kadsurin A 99340-07-5 98%
    Kadsurin A is a new lignan can be isolated from Piper futokadsura. Kadsurin A is a platelet activating factor (PAF) receptor antagonist that weakly inhibits the binding of PAF to its receptor.
    Kadsurin A
  • HY-N3470
    Isomartynoside 94410-22-7 98%
    Isomartynoside is a potent angiotensin converting enzyme (ACE) inhibitor with an IC50 value of 505.9 µM. Isomartynoside is a phenylpropanoid glycoside that can be found in Galeopsis pubescens. IC50: 505.9 µM (ACE)
    Isomartynoside
  • HY-N3486
    Isodunnianol 139726-30-0 98%
    Isodunnianol is a autophagy inducer. Isodunnianol induces autophagy.html" class="link-product" target="_blank">autophagy and increases he expression of pAMPK172, pULK1555,decreases teh expression of pULK1757, SQSTM2. Isodunnianol decreases Doxorubicin (HY-15142A)-induced cardiotoxicity.
    Isodunnianol
  • HY-N3547
    Cassyfiline 4030-51-7 98%
    Cassyfiline (Cassythine) is an aporphine alkaloid. Cassyfiline has potent vasorelaxing effects on precontracted rat aortic preparations with an IC50 of 0.09 μM.
    Cassyfiline
  • HY-N3729
    (-)-Denudatin B 87402-88-8
    (-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels. And (-)-Denudatin B has nonspecific antiplatelet action
    (-)-Denudatin B
  • HY-N3848
    Ermanin 20869-95-8 98%
    Ermanin is a flavonoid isolated from Tanacetum microphyllum. Ermanin potently inhibits iNOS, COX-2 activities, and inhibits platelet aggregation. Ermanin has anti-inflammatory, anti-tuberculous and anti-viral/bacterial properties.
    Ermanin
Cat. No. Product Name / Synonyms Application Reactivity